Guthrie, who will take up the the role in May 2016, is Google’s current managing director of the search giant’s Asia Pacific advertising relationships.
When Scott departs, Guthrie will become the ABC’s first female managing director.
Scott, who announced in September he would depart the broadcaster, has been managing director of the ABC since 2006.
"Michelle brings a unique local and global view to the role, having grown up in Sydney and worked at senior levels here and around the world.
"She brings to the ABC her business expertise, international contacts, record in content-making across an array of platforms, a deep understanding of audience needs and corporate responsibility for promoting issues like diversity."
Guthrie, who joined Google in 2011, was previously a media lawyer and has worked with media companies in Australia and abroad, including Foxtel, BSkyB, and the Asian-based Star television network.
In statement issue by the ABC today, Guthrie said: "Having grown up with the ABC and having been a professional observer of it over the last three decades, I have profound respect for the important role the national broadcaster plays throughout Australia and internationally.
"I would also like to acknowledge the leadership provided by Mark Scott during his tenure as managing director.
"It is fortunate that I will be able to work closely with him during the handover next year."
Guthrie told ABC News 24: "Having the role of being a true independent public broadcaster and being able to deliver fantastic content across platforms, across digital, mobile, television, radio, to all Australians is extraordinary.
"My hope is that I can really contribute to the organisation."