The game, announced today via a short teaser trailer to conclude Sony's PS4 press conference, will be released sometime in 2015.
Sony closed its E3 Press Conference with a short teaser showing the series' protagonist Drake waking up battered and bruised on a riverbank, then trekking off into the jungle.
The Uncharted series has long been both a critics' darling and fan favourite, garnering numerous 'game of the year' awards while clocking up sales in the millions.
It all hasn't been peachy for Naughty Dog, however; as reported by IGN the game's writer Amy Hennig departed Naughty Dog unexpectedly earlier this year, while game director Justin Richmond followed shortly after.
Naughty Dog now has The Last of Us directors Neil Druckmann and Bruce Strale helming up the game. The Last of Us, which was originally a PS3 game, is getting the remastered PS4 treatment for a 29 July release date.
"Several years after his last adventure, retired fortune hunter, Nathan Drake, is forced back into the world of thieves," Naughty Dog said.
"With the stakes much more personal, Drake embarks on a globe-trotting journey in pursuit of a historical conspiracy behind a fabled pirate treasure. His greatest adventure will test his physical limits, his resolve, and ultimately what he's willing to sacrifice to save the ones he loves."
"That's Nathan Drake rendered in full 1080p glory, using the power of our PS4 engine,” Naughty Dog said in reference to the trailer, above.
"All footage you see in the trailer was captured completely in engine. We’re targeting 60fps for Uncharted 4: A Thief’s End, and as you can see, the visual fidelity for our character models will reach new heights. In fact, thanks to the power of PS4, right now Drake's Uncharted 4 model is over double the polygons of Joel from The Last of Us PS3."
Uncharted 4 is available for pre-order on Amazon here.
Sony also used the press conference to announce Grand Theft Auto V is coming to PS4.