The deal will see live streaming of the games on Twitter and connected devices on 3 and 4 June. The event is being held at ESL studios in Sydney.
League of Legends: League of Origin will feature e-sports stars representing New Zealand, Queensland, New South Wales and Victoria who will clash head-on for two days of matches, where only one region can emerge victorious.
"E-sports is growing at a rapid pace in Australia and globally, and this partnership is a great way to tap into the engaged audience of gamers that are already using Twitter as a primary source of content," said Olly Wilton, head of Sports at Twitter Australia.
Daniel Ringland, head of E-sports at Riot Games Oceania, says the livestream on Twitter will be a shortcut for fans in Oceania and around the world, as "Twitter is one of the most engaging platforms for fans of the OPL and OCS e-sports leagues, so it made sense to team up for League of Origin".
"The livestream on Twitter will be a shortcut for fans in Oceania and around the world, as they can both watch and engage on the platform at the same time."
To mark the inaugural League of Legends: League of Origin, Twitter is also launching special tournament emojis. Users can Tweet with #LoLOrigin or one of the team hashtags (#NSWWIN, #NZWIN, #QLDWIN and #VICWIN) to add a custom emoji automatically to their Tweets.
The live content on Twitter will be available globally at Leagueoflegends.twitter.com.