The SUSE Linux Enterprise Server (SLES) distribution, that is cloud-based, includes automated updates through the Azure platform.
SUSE was the first commercial Linux provider to partner with Microsoft, with its parent company at the time, Novell, signing a patent-licensing agreement back in 2006.
In recent years, more of Microsoft's dealings have been with Red Hat, the biggest open source vendor, and Canonical.
A media release said SUSE provided the only commercially supported Linux for HPC available via Microsoft Test Drive.
More than 11,400 applications are certified and supported on SLES in global data centres with Azure.
"With built-in site replication and disaster recovery, customers experience performance, security and reliability comparable to on-premise alternatives," the release claimed.