William Atkins
Thursday, 14 May 2009 18:04
Science -
Health
Page 3 of 3
The researchers concluded in their abstract,
“This first clinical study to target eIF4E in human malignancy demonstrates clinical activity and associated molecular responses in leukemic blasts.”
The May 13, 2009 EurekAlert article “
Novel therapy may prove effective in treatment of 30 percent of cancers” quotes Dr. Borden:
"Our results are the first to show that targeting eIF4E in humans is clinically beneficial."
She states,
"We also found that ribavirin not only blocks eIF4E, it has no side effect on patients." [EurekAlert]
Dr. Assouline adds,
"We had striking clinical improvements with even partial and complete remissions.” [EurekAlert]
Dr. Borden concludes,
"Combination therapy with chemotherapeutic agents may enhance the efficacy of this treatment. Trials in the near future are planned to overcome this and we are looking forward to more complete remissions." [EurekAlert]
"We also hope to test whether ribavirin is as effective in the treatment of other cancers with dysregulated eIF4E. Our laboratory studies suggest this is likely." [EurekAlert]
ClinicalTrials.gov reports on the study in the report “
A Study of Ribavirin to Treat M4 and M5 Acute Myelocytic Leukemia (Borden-001).”