Increase oxygen in blood to strengthen heart

William Atkins
Wednesday, 04 March 2009 05:24

Science - Health

And, they went on to say, “In transgenic mice with severe heart failure caused by cardiac-specific overexpression of Gαq, i.p. ITPP increased exercise capacity, with a maximal increase of 63 ± 7% (P = 0.005). Oral administration of ITPP in drinking water increased Hb p50 and maximal exercise capacity (+34 ± 10%; P < 0.002) in normal and failing mice."

In other words, ITPP given to mice with heart failure increased their exercise capacity by 63%, while ITPP given with drinking water increased exercise capacity by 34%.

They conclude, “Consistent with increased tissue oxygen availability, ITPP decreased hypoxia inducible factor-1α mRNA expression in myocardium. It had no effect on myocardial contractility in isolated mouse cardiac myocytes and did not affect arterial blood pressure in vivo in mice."

"Thus, ITPP decreases the oxygen binding affinity of Hb, increases tissue oxygen delivery, and increases maximal exercise capacity in normal mice and mice with severe heart failure. ITPP is thus an attractive candidate for the therapy of patients with reduced exercise capacity caused by heart failure.

ITPP increases the delivery of oxygen in the blood and increases the exercise capacity in normal mice and mice with severe heart failure.

The researchers hope to parallel these mice studies and apply them to human patients with heart failure so that these heart muscles can regain their strength and more oxygen is circulated throughout their body.