William Atkins
Wednesday, 04 March 2009 06:24
Science -
Health
Page 2 of 3
Their article “
Enhanced exercise capacity in mice with severe heart failure treated with an allosteric effector of hemoglobin, myo-inositol trispyrophosphate ” appears in the February 9, 2009 issue of the journal
Proceedings of the National Academy of Sciences (PNAS).
They stated in the abstract to their paper, “
A major determinant of maximal exercise capacity is the delivery of oxygen to exercising muscles. myo-Inositol trispyrophosphate (ITPP) is a recently identified membrane-permeant molecule that causes allosteric regulation of Hb oxygen binding affinity.”
That is, the more oxygen that is sent to muscles, the more it helps to increase their ability to exercise.
And, ITPP helps to increase the percentage of oxygen send to these exercising muscles.
They went on,
“In normal mice, i.p. administration of ITPP (0.5–3 g/kg) caused a dose-related increase in the oxygen tension at which Hb is 50% saturated (p50), with a maximal increase of 31%. In parallel experiments, ITPP caused a dose-related increase in maximal exercise capacity, with a maximal increase of 57 ± 13% (P = 0.002).”
In mice without severe heart failure (those in good health) ITPP caused the amount of oxygen to increase by 31% and exercise capacity to increase by 57%.
Page three concludes.
