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Newborn mouse repairs its own heart

Science - Biology

U.S. researchers have found that a newborn mammal, in this case a mouse, can heal its heart completely. This discovery could be a big step on the road to preventing and curing heart disease in humans.


Researchers at the University of Texas Southwestern Medical Center have published the results of their experiment in the journal Science.

Their article is entitled 'Transient Regenerataive Potential of the Neonatal Mouse Heart" (Science 25 February 2011: Vol. 331 no. 6020 pp. 1078-1080 DOI: 10.1126/science.1200708).

It is authored by Enzo R. Porrello, Joseph A. Hill , James A. Richardson, and Eric N. Olson Ahmed I. Mahmoud, Emma Simpson, and Hesham A. Sadek, all from the University of Texas Southwestern Medical Center in Dallas, Texas.

They state in the abstract to their paper: 'Certain fish and amphibians retain a robust capacity for cardiac regeneration throughout life, but the same is not true of the adult mammalian heart.'

And, 'Whether the capacity for cardiac regeneration is absent in mammals or whether it exists and is switched off early after birth has been unclear.'

However, due to this information being unknown to scientists, they decided to look into the (hoped for) ability of mammals to regenerate heart muscle early in life.

Page two tells the details of the experiment.