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Harvard researcher contends sirtuins are important in aging
William Atkins
Thursday, 27 November 2008 19:31
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David A. Sinclair, a professor at Harvard University, states that when people age, their bodies have problems in remembering which genes are working and which ones aren’t. Sirtuins, which are proteins found in red wine, could hold the key in controlling the aging process.Sinclair’s team published their results in the journal Cell.
Within the article, Dr. Sinclair says that resveratrol, which is found, for instance, in red wine, activates sirtuins, proteins that help to regulate chromosomes and genes in organisms.
Thus, these sirtuins could hold the key in scientists learning the secrets of the aging process.
Sirtuins, also called silent information regulator 2 (Sir2) proteins, are protein deacetylases/mono-ADP-ribosyltransferases.
They help to regulate important biological pathways. Sirtuins are found in most organisms ranging from simple bacteria to complex humans. They are responsible for cellular regulation in yeast.
The title of the Wednesday, November 26, 2008 Cell article is “SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging.”
Sinclair is associated with the Harvard Univesity Department of Pathology and Glenn Labs for Aging Research. Harvard University is located in Cambridge, Massachusetts, U.S.A.
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