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Science Harvard researcher contends sirtuins are important in aging
Science Harvard researcher contends sirtuins are important in aging | Harvard researcher contends sirtuins are important in aging |
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| by William Atkins | |
| Friday, 28 November 2008 | |
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Page 2 of 2 They state in the abstract to their paper, “Genomic instability and alterations in gene expression are hallmarks of eukaryotic aging. The yeast histone deacetylase Sir2 silences transcription and stabilizes repetitive DNA, but during aging or in response to a DNA break, the Sir complex relocalizes to sites of genomic instability, resulting in the desilencing of genes that cause sterility, a characteristic of yeast aging.” Featured Whitepaper
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Science Discussions"In response to DNA damage, SIRT1 dissociates from these loci and relocalizes to DNA breaks to promote repair, resulting in transcriptional changes that parallel those in the aging mouse brain." "Increased SIRT1 expression promotes survival in a mouse model of genomic instability and suppresses age-dependent transcriptional changes." "Thus, DNA damage-induced redistribution of SIRT1 and other chromatin-modifying proteins may be a conserved mechanism of aging in eukaryotes.” Additional information on sirtuins and the aging process is found in Wednesday, November 26, 2008 The New York Times article “Scientists Find Clues to Aging in a Red Wine Ingredient’s Role in Activating a Protein.” |
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