Science shows why first cigarette produces nausea or pleasure

by William Atkins

Sunday, 10 August 2008

Page 2 of 3 CHRNA5 is a member of nicotinic acetylcholine receptors (nAChRs), which themselves are members of a superfamily of ligand-gated ion channels that provide for the transmission of signals at synapses within the body, such as within the nervous system. NAChRs receptors are opened (triggered) by neurotransmitter acetylcholine, but also are opened by nicotine. Nicotine is an alkaloid found in the family Solanaceae, a group of plants called nightshade. In tobacco, nicotine is the ingredient most responsible for addiction, or the dependence (habit) found with people who smoke cigarettes. In fact, the American Heart Association states, "Nicotine addiction has historically been one of the hardest addictions to break." According to the Addiction news article “If your first cigarette gave you a buzz and you now smoke, a gene may be to blame, study shows,” Pomerleus states, “If cigarette smoking is sustained, nicotine addiction can occur in a few days to a few months. The finding of a genetic association with pleasurable early smoking experiences may help explain how people get addicted — and, of course, once addicted, many will keep smoking for the rest of their lives.” The journal Addiction is published by the Society for the Study of Addiction to Alcohol and other Drugs. Pomerleau states, “The cigarette companies have told us for years that smoking is an individual choice. But it is increasingly clear that for some people that isn't really the case." [WebMD: “Gene Linked to Early Nicotine Addiction”] Page three contains information about other research on the gene responsible for nicotine dependence. << First page <   1 2 3 Next page > Last page - Post your comment >>

 

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